A young man has died at the scene, after being stabbed in Buckle Street, Whitechapel.
Three other men have been treated by paramedics before being taken to the hospital.
After investigating residents of the area, two people were arrested on suspicion of severe bodily harm.
Witnesses are asked to aid with the investigation by contacting police or Crimestoppers anonymous at 0800 555 111.
Words: Kenya Best